Blood brain barrier (BBB)-disruption in intracortical silicon microelectrode implants

Blood-brain barrier disruption in multiple sclerosis.

The blood-brain barrier (BBB) is a complex organization of cerebral endothelial cells (CEC), pericytes and their basal lamina, which are surrounded and supported by astrocytes and perivascular macrophages. Collectively these cells separate and form the compartments of the cerebral vascular space and the cerebral interstitium under normal conditions. Without the BBB, the 'interior milieu' of the...

Consequences of blood-brain barrier disruption

Blood-brain barrier disruption after cardiac surgery.

BACKGROUND AND PURPOSE CNS complications are often seen after heart surgery, and postsurgical disruption of the BBB may play an etiologic role. The objective of this study was to determine the prevalence of MR imaging-detected BBB disruption (HARM) and DWI lesions after cardiac surgery. MATERIALS AND METHODS All patients had an MRI after cardiac surgery. For half the patients (group 1), we ad...

Dynamic Contrast Enhanced (DCE) Perfusion Indices as a Measure of Blood Brain Barrier (BBB) Disruption in Different Stages of Neurocysticercosis

R. Awasthi, A. Verma, V. K. Paliwal, S. K. Verma, K. N. Prasad, R. K. Rathore, and R. K. Gupta Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, Department of Neurology, Sanjay Gandhi Post Graduate Institute o...

Blood Brain Barrier Disruption by Focused Ultrasound and Microbubbles: A Numerical Study on Mechanical Effects

Introduction: Microbubbles are widely used as contrast agent in diagnostic ultrasound. Recently they have shown good potential for applications in the therapeutic field such as drug delivery to the brain. Recent studies have shown focused ultrasound in conjunction with injected micro-bubbles could temporarily disrupt blood-brain barrier and let therapeutic agents transport into...